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eskalith 450 mg But the technique has been criticised. "DTI provides only indirect measures of structural connectivity and is, therefore, different from the well validated microscopic techniques that show the real anatomy of axonal connections," says Marco Catani, of London's Institute of Psychiatry. "Images of the brain derived from diffusion tensor MRI should not be equated to real connections and results should always be interpreted with extreme caution."This point is backed by Prof Heidi Johansen-Berg, of Oxford University, who attacked the idea that brain connections should be considered as hard-wired. "Connections can change throughout life, in response to experience and learning. As far as I can tell, the authors have not directly related these differences in brain connections to differences in behaviour. It is a huge leap to extrapolate from anatomical differences to try to explain behavioural variation between the sexes. The brain regions that have been highlighted are involved in many different functions."